Patents:
- “Signal Recognition Particle as a Novel Antibacterial Target”, Saraogi, I.; Ghosh, S.; Saini, S.; Indian Patent No 383576 granted on 2-12-2021, Application No. 201721032661
- A Novel Dipyridyl Derivative as an Insulin Chaperone”, Saraogi, I.; Gangarde, Y.M.; Das, A.; Indian Patent filed, Application No. 202021053659
Publications:
- Saini, S.; Ghosh, S.; Saraogi, I.*; “Deciphering the effect of designed homo-pyrimidine and mixed-base PNAs on bacterial 4.5S RNA structure and functionality” manuscript under revision
- Das, A.; Sah, P.; Saraogi, I.*; “Dual role of a fluorescent small molecule as a sensor and inhibitor of protein fibrillation” Chem. Asian J. 2023, 18, e202201309 (invited article in special issue on "Women in Chemistry")
- Saini, S.; Shanbhag, C.; Saraogi, I.*; “Chemical Approaches to tackle the silent pandemic of antibiotic resistance” AsiaChem 2023, 164-171 (special issue on "Chemistry in India")
- Shanbhag, C.; Saraogi, I.*; “Bacterial GTPases as druggable targets to tackle antimicrobial resistance” Bioorg. Med. Chem. Lett. 2023 (accepted)
- Upadhyay, T.; Karekar, V.V.; Potteth, U.; Saraogi, I.* “Investigating the functional role of a buried interchain aromatic cluster in Escherichia coli GrpE dimer” Proteins 2023, 91, 108
- Das, A.; Gangarde, Y.M.; Pariary, R.; Bhunia, A.; Saraogi, I.*; “An amphiphilic small molecule drives insulin aggregation inhibition and amyloid disintegration” Int. J. Biol. Macromol., 2022, 218, 981-991
- Bag, S.S.*; Saraogi, I.; Guo, J.; “Expansion of the Genetic Code: Unnatural Amino Acids and their Applications” Front. Chem. 2022, 10:958433
- Mala, P.; Saraogi, I.*; “Enhanced codon-anticodon interaction at in-frame UAG stop codon improves efficiency of non-natural amino acid mutagenesis” ACS Chem. Biol. 2022, 17, 1051-1060
- Das, A.; Shah, M.; Saraogi, I.*; “Molecular aspects of insulin aggregation and various therapeutic interventions” ACS Bio & Med Chem Au 2022, 2, 205-221
- Potteth, U.; Upadhyay, T.; Saini, S.; Saraogi, I.*; “Novel antibacterial targets in protein biogenesis pathways” ChemBioChem 2022, 23, e202100459 (selected as a VIP paper, and part of the ChemBioTalents collection)
- Gangarde, Y.M.; Das, A.; Ajit, J.; Saraogi, I.* “Synthesis and evaluation of arylamides with hydrophobic side chains for insulin aggregation inhibition” ChemPlusChem 2021, 86, 750-757 (Invited article in Special Collection on "Synthesis, Properties and Application of Foldamers")
- Upadhyay, T.; Potteth, U.; Karekar, V.V.; Saraogi, I.* “A stutter in the coiled-coil domain of E.coli co-chaperone GrpE connects structure with function” Biochemistry 2021, 60 (17), 1356-1367
- Bhoge, B.A.; Mala, P.; Kurian, J.S.; Srinivasan, V.; Saraogi, I.* “Selective functionalization at N2-position of guanine in oligonucleotides via reductive amination” Chem. Commun. 2020, 56, 13832-13835
- Gangarde, Y.M.; Sajeev T.K.; Panigrahi, N.R.; Mishra, R.K.; Saraogi, I.*; “Amphiphilic small molecule assemblies to enhance the solubility and stability of hydrophobic drugs” ACS Omega, 2020, 5(43), 28375-28381
- Das, A.; Datta, T.; Gadhe, L.; Koner, A.L.*; Saraogi, I.*; “Biocompatible fluorescent probe for selective detection of amyloid fibrils” Anal. Chem., 2020, 92, 10336-10341
- Das, A.; Gangarde, Y.M.; Tomar, V.; Shinde, O.; Upadhyay, T.; Alam, S.; Ghosh, S.; Chaudhary, V.; Saraogi, I.*; “Small molecule inhibitor prevents insulin fibrillogenesis and preserves activity” Mol. Pharm., 2020, 17, 1827-1834
- Karekar, V.V.; Bhoge, B.A.; Saraogi, I.*; “An expeditious synthetic route to proteomimetic foldamers” New J. Chem. 2019, 42, 556
- Ghosh, S.; Saini, S.; Saraogi, I.*; "Peptide Nucleic Acid Mediated Inhibition of the bacterial signal recognition particle" Chem. Commun. 2018, 54, 8257
- Saraogi, I.*; Bhoge, B.A.; Gangarde, Y.M.; “Supramolecular assemblies in Chemical Biology” in Atwood, J. L., (ed.) Comprehensive Supramolecular Chemistry II, 2017, Vol 4, pp 3-37. Oxford: Elsevier
- Kulikov, O.V.*; Sevryugina, Y.V.; Mehmood, A.; Saraogi, I.; “Characterization of aggregated morphologies derived from mono- and bis-arylbenzamides - potential alpha helix mimetics” New J. Chem. 2017, 41, 7417
- Ariosa, A.R.; Lee J. H.; Wang S.; Saraogi, I.; Shan, S.; “Regulation by a chaperone improves substrate selectivity during co-translational protein targeting” Proc. Natl. Acad. Sci. U.S.A. 2015, 112, E3169–E3178
- Kumar, S.; Schlamadinger, D.E.; Brown, M.A.; Dunn, J.M.; Mercado, B.; Hebda, J.A.; Saraogi, I.; Rhoades, E.; Hamilton, A.D.; Miranker, A.D.; “Islet amyloid-induced cell death and bilayer integrity loss share a molecular origin targetable with oligopyridylamide-based α-helical mimetics” Chem. Biol. 2015, 22, 1
- Kulikov, O.V.; Kumar, S.; Magzoub, M.; Knipe, P.C.; Saraogi, I.; Thompson, S.; Miranker, A.D.; Hamilton, A.D.; “Amphiphilic oligoamide α-helix peptidomimetics inhibit islet amyloid polypeptide aggregation” Tet. Lett. 2015, 56, 3670
- Saraogi, I.*; Akopian, D.; Shan, S* “Real time fluorescence reveals the recognition, commitment, and unloading of cargo during co-translational protein targeting” J. Cell Biol., 2014, 105, 693 (*indicates corresponding author)
- Saraogi, I.*; Shan, S*. “Co-translational protein targeting to the bacterial membrane” Biochim. Biophys. Acta, 2014, 1843, 1433 (*indicates corresponding author)
- Kulikov, O.V.; Thompson, S.; Xu, H.; Incarvito, C.D.; Scott, R.T.W.; Saraogi, I.; Nevola, L.; Hamilton, A.D.; “Design and synthesis of oligoamide-based double alpha-helix mimetics”, Eur. J. Org. Chem., 2013, 3433 (Cover Article)
- Ariosa, A.R.; Duncan, S.S.; Saraogi, I.; Lu, X.; Brown, A.; Phillips, G.; Shan, S.; “Fingerloop activates cargo delivery and unloading during co-translational protein targeting”, Mol. Biol. Cell, 2013, 24, 63
- Saraogi, I.; Zhang, D.; Chandrasekaran, S.; Shan, S.; “Site-specific fluorescent labeling of nascent proteins on the translating ribosome” J. Amer. Chem. Soc. 2011, 133, 14936
- Saraogi, I.; Shan, S.; “Molecular mechanism of co-translational protein targeting by the Signal Recognition Particle” Traffic 2011, 12, 535
- Saraogi, I.; Akopian, D.; Shan, S. “A tale of two GTPases in co-translational protein targeting” Protein Sci. 2011, 20, 1790
- Saraogi, I.; Hebda, J.A.; Becerril, J.; Estroff, L.A.; Miranker, A.D.; Hamilton, A.D.; “Synthetic α-helix mimetics as agonists and antagonists of islet amyloid polypeptide aggregation” Angew. Chem. Int. Ed. 2010, 49, 736
- Saraogi, I.; Hamilton, A.D.; “Recent advances in the development of aryl-based foldamers”, Chem. Soc. Rev. 2009, 38, 1726
- Hebda, J.A.; Saraogi, I.; Magzoub, M.; Hamilton, A.D.; Miranker, A.D.; “A peptidomimetic approach to targeting pre-amyloidogenic states in type II diabetes” Chem. Biol. 2009, 16, 943
- Rosenzweig, B.A.; Ross, N.T.; Tagore, D.M.; Jayawickramarajah, J.; Saraogi, I.; Hamilton, A.D.; “Multivalent protein binding and precipitation by self-assembling molecules on a DNA-pentaplex scaffold”, J. Amer. Chem. Soc. 2009, 131, 5020 (Cover Article)
- Margulies, D.; Opatowsky, Y.; Fletcher, S.; Saraogi, I.; Tsou K.; Saha S.; Schlessinger, J.; and Hamilton A.D.; “Structural basis of surface binding inhibitors of SCF-Kit protein-protein interactions” ChemBioChem 2009, 10, 1955
- Saraogi, I.; Incarvito, C.D.; Hamilton, A.D.; “Controlling curvature in a family of oligoamide α-helix mimetics”, Angew. Chem. Int. Ed. 2008, 47, 9691
- Saraogi, I.; Hamilton, A.D.; “α-helix mimetics as inhibitors of protein-protein interactions”, Biochem. Soc. Trans. 2008, 36, 1414
- Becerril, J; Rodriguez, J.M.; Saraogi, I.; Hamilton, A.D.; “Foldamer-based Molecular Recognition” in Foldamers: Structure, Properties and Applications. Hecht, S. and Huc, I. Eds.; Wiley-VCH, Weinheim, 2007
- Saraogi, I.; Vijay, V.G.; Das, S.; Sekar, K.; Row, T.N.G; C-halogen...π interactions in proteins: a database study; Cryst. Engg. 2003, 6(2), 69
- Saraogi, I.; Mruthyunjayaswamy, B.H.M.; Ijare, Omkar B.; Jadegoud, Y.; Row, T.N.G.; 2-[(4-Bromophenyl)amino]-1-phenylethanone. Acta Cryst. 2003, E59(4), 443
- Saraogi, I.; Mruthyunjayaswamy, B.H.M.; Ijare, Omkar B.; Jadegoud, Y.; Row, T. N. G.; 4-Chlorobenzohydrazide. Acta Cryst. 2002, E58(12), 1341